Access to sexual and reproductive health services and information, including a full range of contraceptive methods, is a fundamental human right critical to the well-being of women and girls. Mixed evidence as to whether the use of hormonal contraceptive methods (HC) are associated with increased risk of women acquiring HIV with interpretation of data challenging, as women using HC may have other behavioural characteristics that could affect their risk of HIV. The ECHO Study is an open-label randomised clinical trial to evaluate whether there are differences in the risk of acquiring HIV infection among users of three highly effective, reversible contraceptive methods. Translating research into policy must account for the needs and concerns of multiple stakeholders including the people it ultimately will affect.